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SUBOXONE® (buprenorphine and naloxone) Sublingual Film (CIII)

How to take SUBOXONE Film

SUBOXONE Film is a discreet and effective treatment for opioid dependence that you can take at home. It comes in 2 mg, 4 mg, 8 mg, and 12 mg doses, allowing your doctor to prescribe the precise dose you need, helping to minimize the risk of overmedication or breakthrough symptoms of withdrawal.

At the right dose, SUBOXONE Film can help reduce your physical withdrawal symptoms and cravings, so you can start working toward recovery. To be sure you're getting the full dose, review the video or slide show from time to time.

Always take your medication exactly as prescribed by your doctor, and see the Medication Guide that accompanies your prescription for full instructions. Call your doctor's office with any questions.

Remember to keep your SUBOXONE Film in a secure place out of the sight and reach of children.

1. SUBOXONE Film is an orange-colored, rectangular film with a white printed logo. Each film comes in unit-dose, child-resistant packaging intended to help reduce the risk of unintentional pediatric exposure. (Fewer unused partial films in open pouches may help reduce the risk of children accessing inappropriately stored medication.)

2. To open your medication package, fold along the dotted line and tear downward at the slit. If you prefer, you can also use scissors to cut along the arrow.

3. Before taking SUBOXONE Film, it's a good idea to drink some water to moisten your mouth. This should help the film dissolve more easily.

4. Make sure your hands are dry. Hold SUBOXONE Film between two fingers by the outside edges of the film.

5. Place the film under your tongue (close to the base either on the left or the right side of the center). The medication in SUBOXONE Film is absorbed into the bloodstream through blood vessels under your tongue.

6. Keep the films in place until they are completely dissolved.

  • While SUBOXONE Film is dissolving, don't chew or swallow—less medication will be absorbed into your bloodstream and you may not get the amount of medicine you need.
  • Talking while the films are dissolving can interfere with how well the medication in SUBOXONE Film is absorbed. You may want to do something that doesn't involve talking, like reading a book or watching television, while waiting for SUBOXONE Film to dissolve. Let family and friends know that you won't be able to answer them or talk on the phone while your medication is dissolving.

7. If you are directed to use 2 films at a time, place the second SUBOXONE Film under your tongue on the opposite side. Try to avoid having the films touch.

8. If you are directed to use a third SUBOXONE Film, place it under your tongue on either side after the first 2 films have dissolved.

9. Take your SUBOXONE Film in the same way each time to ensure consistency in drug absorption.

Keep SUBOXONE Film in a secure place out of the sight and reach of children. Always store the pouches that contain your SUBOXONE Film in a cool, DRY place to protect your medication.

Do not stop taking SUBOXONE Film suddenly. You could become sick and have withdrawal symptoms because your body has become used to the medicine. Ask your doctor how to stop using SUBOXONE Film the right way.

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Watch the video to see how to take SUBOXONE Film. If you have any questions, talk with your doctor.


You should know: Always store SUBOXONE Film safely out of the sight and reach of children. Buprenorphine, the main ingredient in SUBOXONE Film, can cause serious breathing problems in children that could result in death.

SUBOXONE® (buprenorphine and naloxone) Sublingual Film (CIII) is a prescription medicine used for maintenance treatment of opioid dependence as part of a complete treatment plan to include counseling and behavioral therapy.

Important Safety Information

Do not take SUBOXONE® (buprenorphine and naloxone) Sublingual Film (CIII) if you are allergic to buprenorphine or naloxone as serious negative effects, including anaphylactic shock, have been reported.

SUBOXONE Sublingual Film can be abused in a manner similar to other opioids, legal or illicit.

SUBOXONE Sublingual Film contains buprenorphine, an opioid that can cause physical dependence with chronic use. Physical dependence is not the same as addiction. Your doctor can tell you more about the difference between physical dependence and drug addiction. Do not stop taking SUBOXONE Sublingual Film suddenly without talking to your doctor. You could become sick with uncomfortable withdrawal symptoms because your body has become used to this medicine.

SUBOXONE Sublingual Film can cause serious life-threatening breathing problems, overdose and death, particularly when taken by the intravenous (IV) route in combination with benzodiazepines or other medications that act on the nervous system (ie, sedatives, tranquilizers, or alcohol). It is extremely dangerous to take nonprescribed benzodiazepines or other medications that act on the nervous system while taking SUBOXONE Sublingual Film.

You should not drink alcohol while taking SUBOXONE, as this can lead to loss of consciousness or even death.

Death has been reported in those who are not opioid dependent.

Your doctor may monitor liver function before and during treatment.

Keep SUBOXONE Sublingual Film out of the sight and reach of children. Accidental or deliberate ingestion of SUBOXONE Sublingual Film by a child can cause severe breathing problems and death.

Do not take SUBOXONE Sublingual Film before the effects of other opioids (eg, heroin, hydrocodone, methadone, morphine, oxycodone) have subsided as you may experience withdrawal symptoms.

Injecting SUBOXONE may cause serious withdrawal symptoms such as pain, cramps, vomiting, diarrhea, anxiety, sleep problems, and cravings.

Before taking SUBOXONE, tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking SUBOXONE, alert your doctor immediately as there may be significant risks to you and your baby; your baby may have symptoms of withdrawal at birth. If you are pregnant or become pregnant while taking SUBOXONE, you should report it using the contact information provided below.*

Before taking SUBOXONE, talk to your doctor if you are breast-feeding or plan to breast-feed. SUBOXONE can pass into your milk and may harm the baby. Talk to your doctor about the best way to feed your baby if you take SUBOXONE. Breast-feeding is not recommended while taking SUBOXONE.

Do not drive, operate heavy machinery, or perform any other dangerous activities until you know how SUBOXONE affects you. Buprenorphine in SUBOXONE can cause drowsiness and slow reaction times during dose-adjustment periods.

Common side effects of SUBOXONE Sublingual Film include nausea, vomiting, drug withdrawal syndrome, headache, sweating, numb mouth, constipation, painful tongue, redness of the mouth, intoxication (feeling lightheaded or drunk), disturbance in attention, irregular heartbeat, decrease in sleep, blurred vision, back pain, fainting, dizziness, and sleepiness.

This is not a complete list of potential adverse events associated with SUBOXONE Sublingual Film. Please see full Product Information for a complete list.

*To report negative side effects associated with taking SUBOXONE Sublingual Film, please call 1-877-782-6966. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please see full US Product Information and Medication Guide for SUBOXONE Sublingual Film.

For more information about SUBOXONE® (buprenorphine and naloxone) Sublingual Tablets (CIII), please see full US Product Information and Medication Guide.